論文No2406

Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer
Sufang Tian 1, Weidong Hu 2, Li Niu 1, Huan Liu 1, Haibo Xu 3, Shu-Yuan Xiao 4
J Thorac Oncol. 2020 May;15(5):700-704. doi: 10.1016/j.jtho.2020.02.010. Epub 2020 Feb 28.

 

 

 


新型コロナウイルス、COVID-19の剖検、あるいは生検による病理学的データが不足している。


最近肺腺がんで肺葉切除を行った2名の患者が、手術時にCOVID-19であることが後で判明した。
この2名の症例はCOVID-19の病理の研究に重要な機会を与えてくれた。


病理学的検討で、腫瘍とは離れた部位に、2名とも肺水腫、蛋白様物質の浸出液、

局所的な肺胞細胞の反応性過形成、斑状の炎症細胞浸潤、多核巨細胞を認めた。
硝子膜は顕著でなかった。


2名とも手術時点で肺炎症状を呈さなかったので、これらの所見はCOVID-19肺炎の早期相を表しているのかもしれない。

 

 

 



There is currently a lack of pathologic data on the novel coronavirus (severe acute respiratory syndrome coronavirus 2) pneumonia, or coronavirus disease 2019 (COVID-19), from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of the operation. These two cases thus provide important first opportunities to study the pathology of COVID-19. Pathologic examinations revealed that apart from the tumors, the lungs of both patients exhibited edema, proteinaceous exudate, focal reactive hyperplasia of pneumocytes with patchy inflammatory cellular infiltration, and multinucleated giant cells. Hyaline membranes were not prominent. Because both patients did not exhibit symptoms of pneumonia at the time of operation, these changes likely represent an early phase of the lung pathology of COVID-19 pneumonia.